Sustainability in single-use manufacturing: HOF FTU Air-Line
The HOF Freeze-Thaw Units are used in the pharmaceutical and biotechnology industry for the controlled freezing and thawing of single-use bag systems. Previously, a synthetic refrigerant was used for this purpose. The new Air-Line of the HOF FTUs is now based on the use of only air as a refrigerant and therefore not only increases the performance of the system, but also [...]
Case study: Handling API and ADC in a Lyo line
The development and production of highly effective active pharmaceutical ingredients (APIs) and antibody drug conjugates (ADCs), a relatively new class of cancer therapies, places high demands on production facilities and operator safety. In the case study, the requirements for the freeze-drying plant and the associated loading and unloading system are discussed on the one hand, and the tried-and-tested implementation is shown and presented in detail.
Automatic opening/emptying of frozen plasma cylinders
The HOF Debottling Systems were developed to thaw frozen plasma bottles automatically and very precisely in order to be able to remove the remaining ice core with the surrounding liquid from the bottle easily and without any problems after cutting. With this system, HOF is once again providing a system that is technologically highly innovative. At the same time, this solution proves to be [...]
Cleanroom 4.0 - the future of cleanroom technology
The planning and construction of cleanrooms has changed dramatically in recent years: all project participants work together in an integrated manner and in real time right from the planning phase, which saves time and avoids errors later on during construction. However, technical expertise and precision craftsmanship in execution are still a prerequisite. But what does [...]
Fridge qualification: mappings and validation
This presentation highlights the essential topic of GDP/GMP-compliant implementation of distribution measurements (mappings) in the context of refrigerator qualification. It provides an in-depth insight into the regulatory requirements and best practices that are essential for smooth refrigerator qualification. This includes suitable evaluation methods and forms of presentation of the distribution measurements, as well as essential components of the documentation. The practice-oriented presentation focuses on the importance of [...]
Planning, building and operating cleanrooms sustainably, but how?
Hardly any other term has developed as much in recent years as the term "sustainability". But what does sustainability actually mean and what does it have to do with cleanroom technology? First and foremost, it means using existing resources sparingly and reducing the CO2 footprint, especially with regard to climate change. The presentation shows in [...]
Refurbishment of cleanroom floors
The trade fair presentation presents solutions for the refurbishment of floors in cleanrooms. Discover classic and modular flooring systems, customized to reduce downtime and contamination. We present innovative approaches for an efficient environment. Today's solutions offer the advantage that even on problematic and uneven old substrates, immediate installation is possible without the need for substrate preparation. Learn more [...]
The "do's and dont's" of cleanroom construction - avoiding mistakes
The planning and construction of cleanrooms is a very complex task. Many customers who are building a cleanroom for the first time are overwhelmed or underestimate the number of factors that need to be taken into account. In addition, such projects often have to be implemented "on top" of day-to-day business. On the one hand, the presentation shows the potential errors in the procedure [...]
Energy-efficient cleanroom operation: measurement technology & compliance
Sustainable and economical production in the pharmaceutical industry also requires consideration of the energy efficiency of the various processes. Since the operation of clean rooms and clean areas entails a high energy requirement due to air routing and conditioning, there may be potential for optimization in terms of energy consumption. In this presentation, documentary and metrological solutions are presented with regard to [...]
GMP-compliant calibration
For process control in pharmaceutical production, the collection of measurement data directly in the process and indirectly in the process environment is of crucial importance for the quality of the end product. These measurements require reliable measuring equipment that generates valid measurement results. In order to create confidence in the recorded measurement results, the measuring equipment must be calibrated with suitable traceability. Each measuring point must be [...]