The presentation covers the process from load definition to the final qualification of sterilizers, taking into account the challenges of a new load. The focus is on the planning, the measuring system, the OQ work and the qualification of a load. Important standards such as EN 285 and ISO 17665 are emphasized to ensure safe and sterile results. In addition, the need for periodic qualification and validation is emphasized to ensure sterilization within qualified parameters. Important measured values such as equalization time, temperature distribution and sensor deviations are also discussed.