Robotic applications are getting a more important aspect to reduce or best eliminate manual interventions in aseptic fill finish. The usage of robotic systems in pharma is not a new trend. Especially for supporting processes around fill-finish in the cleanrooms, the first applications had already been developed and implemented in the 1990’s. This presentation gives an overview on some of the realized solutions over the years and how they evolved in terms of aseptic design and GMP. In addition, there is a focus on the main requirements that need to be addressed in the grade A environment of RABS and Isolator systems and how different vendors realize those. As a summary, upcoming challenges that are still seen for robotic applications are demonstrated including possible solutions and upcoming trends.