The WIBO® Safe Containment isolators provide personnel, product and room protection when handling toxic substances up to OEB 6. The closed front screen creates a sealed atmosphere, shielding the work area from the surrounding area. An inflatable and pressure-monitored seal is integrated into the frame. To increase operator protection, the unit is also operated in negative pressure. The work area is selectively ventilated with a unidirectional diagonal airflow. The complete air volume in the isolator is thereby exchanged in < 20 s. Highly effective HEPA push-push filters clean both the fresh air and the exhaust air.