In the production of contamination-sensitive goods, automation solutions must meet high requirements with regard to their contamination behavior. Particles or chemical and biological residues released by the equipment into the environment and affect the quality and safety of the products are particularly problematic. 2ndSCIN® is a system for upgrading production systems that are not specifically designed for the cleanroom environment. Due to the individual, flexible enclosure by means of textile layers, the highest cleanliness standards can be achieved. Integrated sensor networks allow AI-based monitoring for continuous condition evaluation.