Purification is a key step in oligonucleotide processing that has unique fluid control challenges. Understanding the fluid mechanics of the process can help determine the best design for specific situations. In his presentation Megan Cider and Jennifer Jacober explore pulsation dampening solutions from Equilibar and how they improve stability in oligonucleotide production. They will compare available dampener designs, show how they minimize pump-induced pulsation and prevent push-through flow, and discuss their impact on process control, product quality, and overall manufacturing efficiency.