When handling hazardous substances (e.g., CMR drugs, API, HPAPI, etc.), certified protective clothing of the highest category III must also be worn in cleanrooms. The presentation highlights the differences between the various clothing materials (disposable and reusable clothing), deals with filtration efficiency and protection against hazardous substances (penetration, permeation), GMP-compliant manufacturing and packaging of cleanroom clothing, and the possible recycling of protective clothing materials.