The planning and setup of cleanrooms and personnel airlocks require balancing diverse demands with stringent regulations. This presentation provides a practical overview of the requirements set by authorities and users, as well as strategies to meet them. It delves into the properties and applications of materials such as stainless steel, HPL, and solid surfaces, highlighting their advantages and limitations. A special focus is placed on hygienic design and cleanability, which are critical for maintaining high standards. Concrete project examples illustrate how these requirements are successfully implemented in practice.