Medicine is advancing rapidly, and the sequencing of the human genome has significantly enhanced our understanding of aging processes. Strategies for a long and healthy life are becoming increasingly actionable. The key lies in analyzing genetic predispositions, implementing personalized prevention, and mitigating vascular risk factors. A comprehensive perspective on these developments is provided by Prof. Dr. Volker Limmroth, co-author of the Spiegel bestseller ‘Longevity Compass’.