Airflow principles in containment facilities aim to establish controlled flow conditions to prevent cross-contamination and particle ingress. Key aspects include the separation of zones, defined pressure cascades, directed airflow (laminar vs. turbulent), appropriate air exchange rates, and effective HEPA filtration. Modern concepts additionally take into account energy optimization and flexible adaptation to process changes, ensuring safety, compliance, and sustainability alike. Practical solutions for product, process and operator safety will be demonstrated using concrete examples to illustrate the added value of modern containment concepts.