VHP technology was introduced to the pharmaceutical industry in the early 1990s and has been continuously developed in numerous GMP applications. The increased injection capacity over the years has enabled the application of this laboratory technology in all production or research volume combinations from rooms to entire manufacturing zones. Several requirements and limitations for biodecontamination have been clarified in Annex 1. This presentation shows the latest approaches and benefits of VHP integration in buildings. It will not only address the efficiency of the technology, but also its traceability and validatable repeatability of the process.