In pharmaceutical production, it is crucial that critical processes take place under the protection of clean (ideally particle- and germ-free) and low-turbulence air. This reduces the risk of germs or particles entering the product and causing contamination. Annex 1 of the EU GMP Guideline also places a strong emphasis on the first-air principle and its verification through flow visualization (smoke study).
But what exactly does this mean, and how can the first-air principle be adhered to?
We'll show you using practical examples!