The requirements for cleanrooms have changed dramatically over the years. Understanding of possible contamination has grown steadily. This is due not only to increasing knowledge of contamination sources, but also to improved technical monitoring capabilities that enable better control. New strategies are increasingly relying on automation and the use of IoT devices to enable real-time monitoring and predictive maintenance. The area of employee training and employee behaviour in the cleanroom is also undergoing a transformation. A journey through the modern cleanroom shows how technological innovations and strict regulations go hand in hand to ensure the highest standards of cleanliness.