The requirements of Annex 1 (EU GMP guidelines) present the pharmaceutical industry with the challenge of developing an effective Contamination Control Strategy (CCT). This presentation will highlight the key components of a successful CCT strategy. This includes the identification of critical control points and the implementation of risk-based measures to prevent microbial, particulate and chemical contamination. It shows how modern technologies such as isolators, RABS and optimized cleanroom designs, combined with organizational measures such as training and an established control culture, help to minimize risks. This is complemented by robust monitoring systems that enable continuous monitoring and improvement of processes. The presentation will show how the pharmaceutical industry can meet the regulatory requirements of Annex 1 and at the same time ensure maximum product safety.