As OpenAI stirs up earthshaking changes to the world and regulations on pharmaceutical and even food industry get more stringent, the demand for more intelligent and competent cleanrooms is expanding. Pharmaceutical, semi-conductor and other industries utilize and integrate artificial intelligence (AI) and robotics to their production process, realizing fully automatic operation. With the introduction of AI and robotics, the production is more intelligently controlled, less workers staying in the cleanroom, dramatically decreasing the source of contamination and heat source. Under this situation, the design and construction of cleanroom have to adapt to this trend. What we can do to cope?