In pharmaceutical manufacturing, sustainability has become a critical objective driven by environmental imperatives and regulatory demands. This article focuses on achieving decarbonization through strategic water reduction, recycling, and recovery. Key areas include re-evaluating heating needs, with a spotlight on energy-efficient methods for Water for Injection (WFI) generation, storage, and distribution to lower carbon emissions and reduce costs. Additionally, water recycling and reclamation strategies are explored, emphasizing the recovery of wastewater and showcasing successful Zero Liquid Discharge (ZLD) implementations. Real-world case studies provide practical insights into challenges, solutions, and outcomes. Finally, the article examines sustainable facility design, highlighting innovative approaches to minimize the environmental impact of pharmaceutical manufacturing while ensuring future competitiveness.