GMP and clean room in the field of ART grows, authorities intensify the inspection of regulatory requirements. It´s a big challenge for IVF centers if the local authority is knocking on the door. Is clean room technology generally bad for ART or is it possible to find compromise solutions? Approaches with focus on patient safety: chances and opportunities. Implementing GMP and clean room technologies in ART in a pragmatic way is topic of this session. Examples of current projects will also be shown.